This reflection on Ethics in One Hundred Years of Solitude is divided in two main parts and issues. In this, the first one, thanks to the intertextual method, the author makes a journey throughout the structure, the characters and the focus of the novel to argue that ethics described there by Gabriel García Márquez is rooted in biblical myths, and how its use is a tool that gives unity to the work, and allows the author to openly reveal the human (...) condition. (shrink)

The second and final part of this collaboration shows and justifies how One Hundred Years of Solitude condenses an ethical approach –with vetero testamentary accent: sin/punishment– about the customs, habits, beliefs and own assessments of human action in the history of Macondo. This novel is a symbol of moral living not only in the region but in the whole world. An ethical matriarchy runs –in wretched solitude– as magma of fears and premonitions, stickler conscience and scandalous relaxation; murder, incest and (...) lust; labor exploitation, injustice, dependency and extravagance, the irreversible slope of no longer have a second opportunity on earth. (shrink)

Our understanding of genomic reorganization, the mechanics of genomic transmission to offspring during germ line formation, and how these structural changes contribute to the speciation process, and genetic disease is far from complete. Earlier attempts to understand the mechanism(s) and constraints that govern genome remodeling suffered from being too narrowly focused, and failed to provide a unified and encompassing view of how genomes are organized and regulated inside cells. Here, we propose a new multidisciplinary Integrative Breakage Model for the study (...) of genome evolution. The analysis of the high‐level structural organization of genomes (nucleome), together with the functional constrains that accompany genome reshuffling, provide insights into the origin and plasticity of genome organization that may assist with the detection and isolation of therapeutic targets for the treatment of complex human disorders. (shrink)

Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, PPN (...) DBS leads were implanted for CL-DBS to treat FoG. The primary outcome of the study was a 40% improvement in medication-refractory FoG in 60% of subjects at 6 months when “on” PPN CL-DBS. Secondary outcomes included device feasibility to gauge the recruitment potential of this four-lead DBS approach for a potentially larger clinical trial. Safety was judged based on adverse events and explantation rate.Findings: The feasibility of this approach was demonstrated as we recruited five subjects with both “on” and “off” medication freezing. The safety for this population of patients receiving four DBS leads was suboptimal and associated with a high explantation rate of 40%. The primary clinical outcome in three of the five subjects was achieved at 6 months. However, the group analysis of the primary clinical outcome did not reveal any benefit.Interpretation: This study of a human PPN CL-DBS trial in medication-refractory FoG showed feasibility in recruitment, suboptimal safety, and a heterogeneous clinical effect in FoG outcomes. (shrink)

The European project European and Latin American Systems of Ethics Regulation of Biomedical Research Project (EULABOR) has carried out the first comparative analysis of ethics regulation systems for biomedical research in seven countries in Europe and Latin America, evaluating their roles in the protection of human subjects. We developed a conceptual and methodological framework defining ‘ethics regulation system for biomedical research’ as a set of actors, institutions, codes and laws involved in overseeing the ethics of biomedical research on humans. This (...) framework allowed us to develop comprehensive national reports by conducting semi-structured interviews to key informants. These reports were summarised and analysed in a comparative analysis. The study showed that the regulatory framework for clinical research in these countries differ in scope. It showed that despite the different political contexts, actors involved and motivations for creating the regulation, in most of the studied countries it was the government who took the lead in setting up the system. The study also showed that Europe and Latin America are similar regarding national bodies and research ethics committees, but the Brazilian system has strong and noteworthy specificities. (shrink)

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)

Neurosurgery for psychiatric disorders, also sometimes referred to as psychosurgery, is rapidly evolving, with new techniques and indications being investigated actively. Many within the field have suggested that some form of guidelines or regulations are needed to help ensure that a promising field develops safely. Multiple countries have enacted specific laws regulating NPD. This article reviews NPD-specific laws drawn from North and South America, Asia and Europe, in order to identify the typical form and contents of these laws and to (...) set the groundwork for the design of an optimal regulation for the field. Key challenges for this design that are revealed by the review are how to define the scope of the law, what types of regulations are required, and how to approach international harmonization given the potential migration of researchers and patients. (shrink)

In recent years, scholars have put forth a formidable defense of Kant's views on moral motivation. Their common goal has been to disclose the emotional dimension of his practical philosophy, an aspect of his thought arguably concealed by a couple of centuries of wrongheaded criticism. Yet a systematic study of the subjective factors that underlie moral performance as Kant understood it was missing. This dissertation tries to fill that gap. I reconstruct his theory of moral performance since 1755, and show (...) why he ends up developing views that have aroused so much criticism. I share many of those criticisms and ask: Why do we have to assume that pure reason has driving mechanisms of its own? In order to answer this question, I focus first on what he calls the aesthetic preconcepts that make the mind susceptible to concepts of pure duty, and conclude that he does not succeed in showing a convincing connection between the moral law and the feeling of respect. Moreover, the theory that he puts forth to overcome this difficulty--the fact of reason--proves to be even more unsatisfactory. Problems beset his view of conscience as well. I show that the conception of the self that supports his definition of conscience is vulnerable to the change of self-deception. I finish with an examination of the religious beliefs that keep moral interest alive, but my conclusion is once more not favorable to Kant. Those beliefs seem to have no power for accomplishing the function that he has reserved for them. It could even be argued that they are intrinsic to the process of self-deception. (shrink)

En el siguiente artículo intentaremos mostrar cómo la definición de Contingencia individual, dentro del discurso de Richard Rorty, genera ciertos problemas. Este autor menciona que debemos deslastrarnos de las siguientes dicotomías conceptuales: objetivo-subjetivo, moralidad-prudencia, apariencia-realidad, esencia-accidente, absoluto-relativo, entre otras. A todo esto Rorty propone un nuevo concepto: Contingencia, el cual sería una definición útil que lograría justificar la desaparición de las concepciones como algo que petrifica el conocimiento y lo hace inútil para entender la realidad, es decir, el conocimiento no (...) sería útil en el momento en que intenta “representar” la realidad porque la vacía. Luego de un recorrido por algunos autores representativos en lo concerniente a la conceptualización de “esencia”, nuestra conclusión es que la definición de Contingencia rortyana es una nueva petrificación de la realidad, es decir, Contingencia también termina “representado” lo que es “real”. Is Contingency an essence? A review of the theory of Contingency in Richard RortyIn the following article, it is shown how the definition of individual Contingency, within the discourse of Richard Rorty, produces certain problems. This author mentions we should put an end of the following conceptual dichotomies: objective-subjective, morality-prudence, appearance-reality, essence-accident, and absolute-relative, among others. To all this Rorty proposes a new concept: Contingency, which could be a useful definition which would achieve the justification of the loss of conceptions as something that petrifies knowledge, and renders it useless for understand reality, i.e., knowledge is not useful in the moment you try to "represent" reality because simply empties it. After a tour of some representative authors with regard to the conceptualization of "essence", our conclusion is that the definition of Rorty's Contingency is a new petrifaction of reality, i.e., Contingency also ends "representing" what is "real.". (shrink)

The Gait Deviation Index is a multivariate measure of overall gait pathology based on 15 gait features derived from three-dimensional kinematic data. GDI aims at providing a comprehensive, easy to interpret, and clinically meaningful metric of overall gait function. It has been used as an outcome measure to study gait in several conditions: cerebral palsy, post-stroke hemiparetic gait, Duchenne muscular dystrophy, and Parkinson’s disease, among others. Nevertheless, its use in population with Spinal Cord Injury has not been studied yet. The (...) aim of the present study was to investigate the applicability of the GDI to SCI through the assessment of the relationship of the GDI with the Walking Index for Spinal Cord Injury II. 3D gait kinematics of 34 patients with incomplete SCI was obtained. Besides, 3D gait kinematics of a sample of 50 healthy volunteers was also gathered with Codamotion motion capture system. A total of 302 and 446 strides were collected. GDI was calculated for each stride and grouped for each WISCI II level. HV data were analyzed as an additional set. Normal distribution for each group was assessed with Kolmogorov-Smirnov tests. Afterward, ANOVA tests were performed between each pair of WISCI II levels to identify differences among groups. The results showed that the GDI was normally distributed across all WISCI II levels in both iSCI and HV groups. Furthermore, our results showed an increasing relationship between the GDI values and WISCI II levels in subjects with iSCI, but only discriminative in WISCI II levels 13, 19, and 20. The index successfully distinguished HV group from all the individuals with iSCI. Findings of this study indicated that the GDI is not an appropriate multivariate walking metric to represent the deviation of gait pattern in adult population with iSCI from a normal gait profile when it is compared with the levels of walking impairment described by the WISCI II. Future work should aim at defining and validating an overall gait index derived from 3D kinematic gait variables appropriate for SCI, additionally taking into account other walking ability outcome measures. (shrink)

RESUMENLa segunda etapa del pensamiento filosófico de Ayer es conocida como «fenomenalismo analítico» y se caracteriza por su afirmación: lo que conoce el sujeto no son más datos sensoriales. Esto conlleva la necesidad de de crear lo que se conoce como el lenguaje de «los datos sensoriales», que debería ser previo al lenguaje ordinario y al que podría traducirse el primero mediante la provisión de una serie de reglas con este objeto. Los problemas y las críticas, conectados con la caracterización (...) de que sea un «dato sensorial» surgieron muy pronto y tales problemas provocaron que el propio Ayer fuese obligado a redefinir su posición filosófica.PALABRAS CLAVE:DATO SENSORIAL, FENOMENALISMO ANALÍTICO, ENTIDAD CUASIFÍSICA, ENTIDAD LINGÜÍSTICAABSTRACTThe second phase of Ayer’s philosophical thought is known as «analytical phenomenalism» and is characterized by his assertion: what the subject knows is not but sense data. This involved the need of creating what is known as the language of «sense data», which should be prior to the ordinary language, and into which the last one could be translated, by means of providing a series of rules on this purpose. Problems and criticism, linked to the characterization of what a «sense datum» could be, arose very soon, and such problems and criticism forced Ayer to redefine his philosophical position.KEY WORDS.SENSE DATUM, ANALYTICAL PHENOMENALISM, QUASI-PHYSICAL ENTITY, LINGUISTIC ENTITY. (shrink)

Luis de Molina was a leading figure in the remarkable sixteenth-century revival of Scholasticism on the Iberian peninsula. Molina is best known for his innovative theory of middle knowledge. Alfred J. Freddoso's extensive introductory essay clears up common misconceptions about Molina's theory, defends it against both philosophical and theological objections, and makes it accessible to contemporary readers.

Many years before Adam Smith, numerous theologians associated with the School of Salamanca, such as Domingo de Soto, Juan de Lugo, Juan de Mariana, Luís Saravia de la Calle, Martin de Azpilcueta, Luis de Molina, Leonard Lessius, Thomas Cajetan, and Francisco Garcia had made great strides in the development of economics. Specifically, these theologians, otherwise known as the “Scholastics,” analyzed and argued against price and wage controls by explaining that the only “just” prices and wages are those that are (...) set by the market, examined and pushed back against prohibitions on usury, understood the concept of time preference, and helped develop monetary theory in multiple ways. They also demonstrated that all of this was consistent with the Catholic religion. This paper analyzes the ways in which these early theologians contributed to the development of economics and reconciled it with their Catholicism. (shrink)

This book aims to contribute significantly to the understanding of issues of value which repeatedly emerge in interdisciplinary discussions on space and society. Although a recurring feature of discussions about space in the humanities, the treatment of value questions has tended to be patchy, of uneven quality and even, on occasion, idiosyncratic rather than drawing upon a close familiarity with state-of-the-art ethical theory. One of the volume's aims is to promote a more robust and theoretically informed approach to the ethical (...) dimension of discussions on space and society. While the contributions are written in a manner which is accessible across disciplines, the book still withstands scrutiny by those whose work is primarily on ethics. At the same time it allows academics across a range of disciplines an insight into current approaches toward how the work of ethics gets done. The issues of value raised could be used to inform debates about regulation, space law and protocols for microbial discovery as well as longer-range policy debates about funding. (shrink)

Autor de vasta e rigorosa obra de investigação histórico-filosófica, Domingos Maurício participou no corpo incial dos redactores da. Revista Portuguesa de Filosofia, cabendo-lhe a autoria do texto programático de abertura da publicação, em 1945. Como investigador, as directrizes de trabalho que Domingos Maurício prosseguia ligavam--se, em parcela significativa, àquelas que viriam a ser definidas e executadas pela própria Revista, daí resultando o interesse de uma análise em termos de recíproca aproximação, para efeitos deste estudo. A recuperação do prestígio intelectual dos (...) Inacianos, e a revisão crítica do processo que engendrara a lenda denegridora da Companhia de Jesus no nosso País; a valorização da Metafísica cristá e da Teologia de inspiração tomista; a demonstração da grande densidade filosófica do Curso Conimbricense, e da valia do labor especulativo de luminares do Pensamento moderno, como Pedro da Fonseca, Franciso Suárez e Luís de Molina; o mérito e projecção cultural da Universidade de Éevora e do Colégio das Artes de Coimbra, durante a administração jesuíta, tais eram as metas e os temas de um vasto programa que Domingos Maurício empreendera. A única via possível para realizar esse vasto programa foi a da objectividade da investigação histórica, da erudição verdadeiramente rigorosa, da crítica exigente. A realização destes objectivos constitui, a nosso ver, o grande merito historiográfico de Domingos Maurício, e isso lhe conquistou um lugar ímpar na História da Filosofia e na História das Ideias em Portugal. /// Auteur d'une vaste et rigoureux travail de recherche histoire-philosophique, Domingos Maurício étail menibre du groupe initial des redacteurs de la Revista Portuguesa de Filosofia, et fut l'auteur du texle-programme lors de l'apparilion de la publication en 1945. Coirune chcrchcur, les lignes directrices du travail de Domingos Maurício croisent de façon significative celles qui en viendraient à l'être définies et mises en pratique par la Revue même: il en résulte un net intérét pour une analyse en tennes d'approchc réciproque en vue de cette étude. La récuperation du prestige intellecluel des disciples de S. Ignacc et la révision critique du procès qu'avait provoqué la légende dénigranl la Compagnie de Jésus dans noire pays: la valorisation de la Métaphysique chrétienne el de la théologie d'inspiralion thomiste; la démonstration de la grande densite philosophique du "Cursus Conimbricensis", et la qualité du travail spéculatif des flambeaux de la pensée moderne, comme Pedro da Fonseca, Francisco Suárez et Luis de Molina; le mérite de la projection culturelle de l'Université d'Évora et du College des Arts de Coimbra durant radministration jésuite, tels étaient les buls el les thèmes d'un vaste programme que Domingos Maurício avait entrepris. L'unique voie possible pour réaliser ce vaste programme ful celle de l'objectivité de la recherche historique, de l'érudition vraiment rigoureuse, de la critique exigente; la réalisation de ces objectifs consume, à notre avis, le grand mérite historiographique de Domingos Maurício, ce qui lui valut une place sans égal dans la Philosophic et l'Histoire des Idées au Portugal. /// Author of many works in the history of philosophy, Domingos Maurício belong the original editorial team responsable for the publication of the Revista Portuguesa de Filosofia; in fact, the opening text of the first issue of the review (1945) was witten by him. The direction taken in his research can be seen in the issues of the Revista: the recuperation of the intelectual prestige of the Inacians and a critical account of the process by which a negative history of the Society of Jesus was produced in our country; the valorization of Christian Metaphysics and Thomistic theology; the demonstration of the philosophical worth of the "Curso Conimbricense", and the value of authors such as Pedro da Fonseca, Francisco Suárez, and Luis de Molina; the cultural importance of the Universidade de Évora and the Colégio das Artes in Coimbra under the administration of the Jesuits. (shrink)

Metaphysicians go on busily doing metaphysical thinking all over the world, and apparently with a modicum of self-assurance that they are not talking nonsense or pursuing an illusory will-of-the-wisp. Yet other philosophers of empirical, analytical, phenomenological, or other turns of mind seem to have more and more difficulty in understanding just how metaphysicians give meaning and positive content to the vast abstract concepts by which they seek to describe and explain the entire spectrum of reality extending far beyond present or (...) perhaps even possible human experience. Since there is no way of gaining direct insight into dimensions of reality beyond human experience, and since in order to be applied to the whole range of reality these concepts must abstract from purely human experience, it is hard for them to see—and it is a serious problem in itself—how these all-embracing terms can be anything more than empty, formal, verbal symbols or conceptual constructions, with no positive existential content describing reality itself across its whole spectrum. Even the metaphysician himself, though when left alone he may have a sure sense of how to do metaphysical thinking fruitfully, when questioned to explain and justify what he is doing, and is convinced is worth doing, can feel embarrassed and struck dumb as to how to articulate and justify the principles behind the procedures he is following. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:EPILOGUE Robert J. Daly, SJ. Boston College April 2002 Iwill arrange my comments under four headings: (1) what we had hoped to accomplish; (2) what we actually did accomplish; (3) what we may have learned from this; (4) what this might now enable us to do in thefuture. This epilogueisbeingwritten in April, 2002,twenty-twomonths after the conference. To draw what good we can from this delay, writing at this distance (...) allows me to summarize and draw conclusions with, perhaps, a bit more balance. On the other hand, my listening again to the audio record in the course ofpreparing this publication has enabled me to relive something of the original experience. (1)As I indicated in the introduction, we had unrealistically hoped that, by the time ofthe conference, the five presenters, and perhaps also the twoprincipals inthe "Girard-Lonergan Conversation," wouldhavealready exchanged with each other not just first drafts, but even second drafts of their papers, and that the conference itself would then be invited to join a conversation that was already well under way. As it turned out, I couldn't muster the organizational skills and resources needed to achieve this. But reflecting after the fact, I can see that so carefully detailed a preparation might have been counterproductive. Carrying out our original plan might have been at the cost ofimposing more ofa Western analytic pattern on our discussion ofother traditions, and of!thus smothering from the outset some of the insight that did occur. We had also hoped that the opening "Girard-Lonergan Conversation" would provide an analytic resource for the rest of the meeting. But that did not happen to any great extent. (2)The proximate preparation for this conference began with a draft version ofmy paper being sent to the other major presenters. I opened with 194Robert J. Daly, SJ. a series of brief sketches of salient points in the often unhappy but also occasionally felicitous history ofChristianity on this theme ofviolence and institution. Then, after emphasizing the importance of distinguishing between the normative and the descriptive, I tried to make some sense, both rational and theological, of all this data, especially by reflecting on the influences and consequences ofthe belief in hell, on the one hand, and the hope of universal salvation, on the other. The next major religious theme was Judaism. Reuven Kimelman provided a detailed—and, for some, overwhelming—glimpse of the way the talmudic traditions deal with the theme of war and its restrictions. This highly text-oriented and interpretation-of-texts driven presentation seemed to many, at first, to be irrelevant to mimetic theory and to the need to be confronting actual violence. But, in the course of Sandor Goodhart's response, and in the course ofthe at times spirited discussion that followed, we began to understand that how one interprets texts and traditions, and how these are played off against each other, is indeed fundamental to the way Jews typically try to deal with the practical challenges of violence. Qamar-ul Huda's presentation on IsIamfocused stronglyonthe way the spiritual teachings of Islam—i.e., islam as a religion rather than Islam as a political or national institution—foster peace. The initial reaction was somewhat similarto the reaction to Kimelman's paper: disappointment that Huda was not talking more directly about contemporary Muslim extremist violence. But here, too, the discussion enabled us to catch a glimpse both of the inner spiritual resources of Islam, and of the limitations ofthe range of concerns that Westerners typically bring to the table. Francis Clooney, in his presentation ofHinduism, strongly emphasized the great variety in Hinduism, stressing that one cannot speak ofHinduism as such. Much of this variety comes from the several millennia of Hindu history, and from the complex relationships to Buddhism and Jainism which, themselves, are important parts of Hindu history, and also from the fact that only recently have Hindus, after centuries of Moslem or Colonial domination, once again returned to positions of political and military power. Finally, Christopher Ives's presentation on Buddhism, in a way similar to my presentation on Christianity, but more extensively or more consequently, pointed out the various ways in which Buddhism has been politically and... (shrink)

Despite an enormous amount of literature on St Augustine of Hippo, this work provides the first examination of what he taught about the resurrection of Jesus Christ. Augustine expounded Christ's resurrection in his sermons, letters, Answer to Faustus the Manichean, the City of God, Expositions of the Psalms, and the Trinity. Saint Augustine on the Resurrection of Christ: Teaching, Rhetoric, and Reception explores what Augustine held about the centrality of Christ's resurrection from the dead, the agency of Christ's resurrection, and (...) the nature of his risen existence. Leading scholar, Gerald O'Collins, investigates the impact of his resurrection on others and his mediatory role as the risen High Priest. O'Collins then unpicks Augustine's rhetorical justification for the resurrection of Christ: evidence from creation, human history, and the desires of all human beings. This groundbreaking study illustrates the enduring significance of Augustine's teaching on and apologetic for the resurrection, and updates, augments, and corrects what Augustine held. (shrink)

Josef Pieper’s insight into Aquinas’s metaphysics, that “createdness determines entirely and all-pervasively the inner structure of the creature,” applies equally to philosopher William Desmond.1 For at the heart of Desmond’s metaphysical project lies a refusal to take creation for granted, a challenge to Bertrand Russell’s assertion that “the universe is just there, and that’s all.”2 Desmond work aims at “renewing metaphysical astonishment before the enigma of being that was, and is, and always will be too much for us, in excess (...) of our groping efforts.”3 This “enigma of being” arouses a sense of astonishment at creation’s givenness, “that it is,” and at creation’s contingency, for all that is “might not have been .. (shrink)

Charles S. Peirce has a great deal to contribute both to understanding and to solving many of the philosophical problems which puzzle contemporary thinkers. In fact it is probably true that in some ways philosophers of our time are in a better position to understand Peirce's thought than those of his own day. In this paper I would like to consider two puzzling notions: 1) the substantiality of things, and 2) the foundations of human knowledge.

This is an extremely helpful book, superbly edited by Professor Molina, whose earlier book Existentialism as Philosophy provided a helpful introduction to existentialism as a serious, systematic philosophy. Molina successfully avoids all temptations to exploit the faddish quality of existentialism. After all these years, even the most protected, sequestered, academic institutions have had their resident left-bank habitue. And so one could play about lightly with Nietzsche and Kierkegaard, sell lots of books, sound serious, and leave still another generation (...) impressed with the shallow and the superficial. But Molina is at all times the scholar. He refuses to couch difficult concepts in popular terms. And the result is a weighty, but well-written companion volume to the earlier expository work, providing the reader with an interesting selection of primary sources in the philosophy of existentialism. The authors represented are Kierkegaard, Nietzsche, Husserl, Ortega y Gasset, Sartre, Tillich, Heidegger, Gendlin, and Merleau-Ponty. Each selection is prefaced by Molina's interpretation of the material, excellently written and philosophically sound. The book ought to be a standard text for courses in Existentialism.--W. A. J. (shrink)